It all depends on what the engines fuel & air flow needs are.... What goes in must come out, just a big air compressor... Depends on what the intended usage will ultimately be... If properly set up multiple carbs didn't work/run better/faster & do you actually think a NHRA Pro-Stoker or Top-Sportsman or Pro-Mod cars {or whom ever} would run split Dominators or Dual Dominators, on a custom sheet metal tunnel ram, if they actually thought a single lower manifold & big 4bbl carb would do better ?? I think not, because they can't & won't perform better... Again it really Depends on what the usage will be... Most cars should probably have a simple single carburetor on a moderate aluminum high rise setup.... But also most people, can't &/or won't, be able to "properly tune a carburetor" for performance anyway, let alone tune their way out of a paper damn bag either...LOL... IMHFO The NASCAR example is completely, different because without restrictor plates the single larger carburetor had better response in corners, it's the rules also, but the multiple carb setups had better top speeds... But mostly because of float position, weight & design or type of boosters &/or type of squirter's & accel. pumps... IMHFO it's just what air flow the specific engine can handle, or needs, the multiple carbs are just another tuning aid... Some setups won't make much, if any more power, allot of reasons why, than the properly sized & set up single carburetor, on a marginal engine combo, with some multiple carb set ups, may have also a slight tunnel ram effect, that will give some added HP/TQ, if properly tuned & sized for the engine combo... Cost &/or rules, also plays a very big part of single vs multiple carb applications also, in todays world, EFI or Mech. FI is the best way to go, but a well tuned multiple carb set up is very easily made street worthy, especially with all the trick carb stuff you can get today.... Cylinder head & intake Porting, valve size, proper valve springs etc. &/or the exhaust manifolds size/style vs header tube style, length, size, shape even & what size style length of collectors, or even ignition work or matched components, for your specific combo, is so much more important {to a point}, but people have these obsessions with carburetors, will cheap out on exhaust, cheap headers or no professional cylinder head & manifold porting work.... Opinions will Vary Vastly, I'm sure....