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I have a 750 holley dp on my '74 motorhome 440 with headman hedders and dominator intake. only had to turn the screws about 3/4 out but it runs good.
I have a cheap china pump I bought from rock auto just to make my 440 run. I'll let you know if it fails.
Yeah I would say check for leaks around gaskets. We used to use carb cleaner or starting fluid backin the day and spray a little on the suspected...
I'd Check for Vacuum leaks and air leaks at carb base too.