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I have 295x50x15 on the Rallye wheel 15x8 with standard offset on my '70 GTX - probably exactly the same wheel house clearance as yours. No issues at all....except a telltale rub mark up the top when some fat bastards sat in the back.
Had a set of 305's on my Charger with no mods, they were on 10" wide rims. They were actually a friends who has them on a 69 RR, I'll be putting 305's on mine next time around. The rim is the trick, has to have the right offset (backspacing) which should be zero offset or 5" backspacing on a 10" rim.
I have M/T 28 x 12.5 x 15 tires mounted on 10" rims with a 5-1/2" offset. The fit in my 69 RR with about 1/4" clearance at the tub. They clear everywhere else.
A 295 tire is only 11.75" wide so clearance should not be an issue