Compression ratio, rear gearing, tire size, available gas octane, etc. need to be figured in. On a new motor it's always wise to be conservative with the initial timing, total timing and the advance curve. If it's an MSD Pro Billet distributor I would start with the factory set-up, which should be the stiffest springs (silver) and the blue advance stop bushing, which will give you 21* of mechanical advance, all in by 4,000 rpm. If you set your initial advance at 13-14*, you get a total of 34-35*. This is a very safe tune for firing and breaking in a new motor. After the motor has been broken in and it's got some miles on it you can begin to alter the total timing, initial timing and lower the rpm at which the timing is completely in. The MSD manual has good suggestions for doing this. BTW, there is no perfect tune that works for every motor, but there is a perfect tune that will work for your motor...
I recommend reading all you can find on ignition tuning and then experimenting from there. Listen carefully for "pinging" under heavy acceleration. It'll let you know when you've gone too far... Good luck. Feel free to PM me if you have questions.
Dave