When I looked at the shape of the wheel wells in my car, I wondered WHY would they make them the way that they did . . . but they did.
Here's a piece of metal that I cut out of the "hump" area - the outer wheel well above the wheel opening of the quarter panel.
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On the left, would be inside the wheel well, on the right is your quarter panel. What doesn't make sense is that the tire would clear at the bottom of the well, but as it moved higher inside, the metal bends inward ( "the hump" ) and the tire would hit it. I cut most of this outer wheel well out of my car and replaced it with a flatter piece of steel so that if the tire cleared at the bottom, it would also clear at the top.
Hope that makes a little more sense on the de-humping of the wheel wells - it gains spacing on the outboard side of the tire in the well.
I've got a bunch of pictures in my build thread that shows me cutting and moving the inner wheel well against the frame rail to add additional space for the nice big fat tires on the inboard side of the tire.
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Added some lines on the picture to try and better show you the details . . . hope this helps . . .