one needs to run as much initial as can be tolerated by the engine, then limit the mechanical weight slots so there is not too much advance that pinging/detonation occurs.
then tailor the vacuum advance curve to get the maximum advance possible under cruise conditions [very light load] as possible.
E-booger did an excellent article on this very subject in Mopar Action magazine many years ago, and if one follows his suggestions, quite an improvement in engine performance can be obtained.
i really recommend one read this article if possible.
just my opinion. [and i'm old, so don't beat me too hard !]
your mileage will vary.