My 451 ran a little warm when I first was breaking it in. It was 102 on a hot july afternoon, slight uphill climb on an interstate, 12 to 1 C/R, started pinging and detonating so bad I had to shut er down, turn around and go downhill. Got to the nearest garden hose and sprayed the radiator while the engine was running. That cooled it off after a few minutes! No harm done, it runs mid 12s @ 110 MPH now.
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As has been said, lean condition, retarded timing, new parts mating to each other, which causes higher than normal internal friction, all this contributes to more heat build up. If you get too much heat and it begins to ping, detonation will follow which can ruin the engine.