depending on the headers and if they're ceramic coated or not, there's also the factor of under hood heat if that's a concern. If you do go headers, I'd spend the extra coin and buy the ceramic coated versions.
I had HP manifolds and they were fine. I switched to headers and debated pricey long tube TTI's or Schumacher tri-Y's. I went with the Tri-Y's. No seat of pants difference at all, but long tube headers should definitely make a difference. I also was surprised with my tri-Y's the exhaust note sound was deeper and less raspy with the HP manifolds. I liked the HP manifolds tone better. If I were to do it again, I would have went with long tube TTI's or kept the HP's. My tri-Y's are fine, but not the improvement I was expecting. I also found out as a first time header user, about the need to check and re-tighten header bolts often. Mine loosened up in less than 4000 miles and when I installed them I had tightened 3 times in between driving cycles in the first 200 miles. I never had that problem with HP manifolds. I've since installed header bolt locks to keep them from backing out (those were a pain to install as well.)